{"id":35919,"date":"2024-07-08T10:56:16","date_gmt":"2024-07-08T08:56:16","guid":{"rendered":"https:\/\/irbstage.vetim.ch\/?p=35919"},"modified":"2024-07-08T11:03:56","modified_gmt":"2024-07-08T09:03:56","slug":"intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition","status":"publish","type":"post","link":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/","title":{"rendered":"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition"},"content":{"rendered":"<p><strong>A new study published by the Grassi laboratory and collaborators in \u201cCell Reports Medicine\u201d demonstrates that releasing the inhibitory effect of adenosine-triphosphate (ATP) on secretory IgA production in the gut protects from enteropathy and restores growth in malnourished newborns<\/strong><\/p>\n<p>Bellinzona \u2013 July 5 2024 \u2013\u00a0 Living in impoverished environments is the cause of stunting for almost 150 million children under 5 years of age. In these children, environmental enteric dysfunction (EED), a disease characterized by diarrhea and impaired nutrients absorption, is also variably associated to slowed neurocognitive development and reduced responsiveness to oral vaccines. A causal relationship has been established between the intestinal microbiota, EED and growth stunting. The Grassi lab has developed an experimental model of intergenerational malnutrition, which reproduces all the cardinal features of EED in newborns from malnourished mothers. This model was exploited to show that amplification of intestinal secretory IgA (SIgA) in malnourished pups by administration of an ATP-degrading <em><i>Lactococcus lactis<\/i><\/em> biotherapeutic, restores the conditioning of commensal microbes by SIgA coating, thereby improving the growth and intestinal fitness of malnourished animals. The study suggests SIgA amplification may exert a dominant function in correcting EED and its consequences on host organism.<\/p>\n<p>The study was performed by Lisa Peruzza and other members of the Grassi lab in collaboration with the University of Milan, University of Zurich, University Hospital of Wurzburg, and supported by the Bill &amp; Melinda Gates Foundation and the Swiss National Science Foundation.<\/p>\n<p><a href=\"https:\/\/www.cell.com\/cell-reports-medicine\/fulltext\/S2666-3791(24)00352-5\">Link to the Scientific Article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study published by the Grassi laboratory and collaborators in \u201cCell Reports Medicine\u201d demonstrates that releasing the inhibitory effect of adenosine-triphosphate (ATP) on secretory IgA production in the gut protects from enteropathy and restores growth in malnourished newborns Bellinzona \u2013 July 5 2024 \u2013\u00a0 Living in impoverished environments is the cause of stunting for [&hellip;]<\/p>\n","protected":false},"author":140,"featured_media":35916,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-35919","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition - IRB USI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition - IRB USI\" \/>\n<meta property=\"og:description\" content=\"A new study published by the Grassi laboratory and collaborators in \u201cCell Reports Medicine\u201d demonstrates that releasing the inhibitory effect of adenosine-triphosphate (ATP) on secretory IgA production in the gut protects from enteropathy and restores growth in malnourished newborns Bellinzona \u2013 July 5 2024 \u2013\u00a0 Living in impoverished environments is the cause of stunting for [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/\" \/>\n<meta property=\"og:site_name\" content=\"IRB USI\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-08T08:56:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-08T09:03:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/irbstage.vetim.ch\/images\/Slide1-4.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Viviana Granelli\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Viviana Granelli\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/\"},\"author\":{\"name\":\"Viviana Granelli\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#\\\/schema\\\/person\\\/e3529a53127a78cf8ead39a83c87f29b\"},\"headline\":\"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition\",\"datePublished\":\"2024-07-08T08:56:16+00:00\",\"dateModified\":\"2024-07-08T09:03:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/\"},\"wordCount\":247,\"publisher\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/irbstage.vetim.ch\\\/images\\\/Slide1-4.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/\",\"url\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/\",\"name\":\"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition - IRB USI\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/irbstage.vetim.ch\\\/images\\\/Slide1-4.jpg\",\"datePublished\":\"2024-07-08T08:56:16+00:00\",\"dateModified\":\"2024-07-08T09:03:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/#primaryimage\",\"url\":\"https:\\\/\\\/irbstage.vetim.ch\\\/images\\\/Slide1-4.jpg\",\"contentUrl\":\"https:\\\/\\\/irbstage.vetim.ch\\\/images\\\/Slide1-4.jpg\",\"width\":1280,\"height\":720},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/news\\\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"News\",\"item\":\"https:\\\/\\\/irbstage.vetim.ch\\\/.\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#website\",\"url\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/\",\"name\":\"IRB USI\",\"description\":\"Institute for Research in Biomedicine\",\"publisher\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#organization\",\"name\":\"IRB USI\",\"url\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/irbstage.vetim.ch\\\/images\\\/IRB-Usi.svg\",\"contentUrl\":\"https:\\\/\\\/irbstage.vetim.ch\\\/images\\\/IRB-Usi.svg\",\"width\":98,\"height\":43,\"caption\":\"IRB USI\"},\"image\":{\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/irbstage.vetim.ch\\\/it\\\/#\\\/schema\\\/person\\\/e3529a53127a78cf8ead39a83c87f29b\",\"name\":\"Viviana Granelli\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition - IRB USI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/","og_locale":"it_IT","og_type":"article","og_title":"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition - IRB USI","og_description":"A new study published by the Grassi laboratory and collaborators in \u201cCell Reports Medicine\u201d demonstrates that releasing the inhibitory effect of adenosine-triphosphate (ATP) on secretory IgA production in the gut protects from enteropathy and restores growth in malnourished newborns Bellinzona \u2013 July 5 2024 \u2013\u00a0 Living in impoverished environments is the cause of stunting for [&hellip;]","og_url":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/","og_site_name":"IRB USI","article_published_time":"2024-07-08T08:56:16+00:00","article_modified_time":"2024-07-08T09:03:56+00:00","og_image":[{"width":1280,"height":720,"url":"https:\/\/irbstage.vetim.ch\/images\/Slide1-4.jpg","type":"image\/jpeg"}],"author":"Viviana Granelli","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"Viviana Granelli","Tempo di lettura stimato":"2 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/#article","isPartOf":{"@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/"},"author":{"name":"Viviana Granelli","@id":"https:\/\/irbstage.vetim.ch\/it\/#\/schema\/person\/e3529a53127a78cf8ead39a83c87f29b"},"headline":"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition","datePublished":"2024-07-08T08:56:16+00:00","dateModified":"2024-07-08T09:03:56+00:00","mainEntityOfPage":{"@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/"},"wordCount":247,"publisher":{"@id":"https:\/\/irbstage.vetim.ch\/it\/#organization"},"image":{"@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/#primaryimage"},"thumbnailUrl":"https:\/\/irbstage.vetim.ch\/images\/Slide1-4.jpg","articleSection":["News"],"inLanguage":"it-IT"},{"@type":"WebPage","@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/","url":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/","name":"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition - IRB USI","isPartOf":{"@id":"https:\/\/irbstage.vetim.ch\/it\/#website"},"primaryImageOfPage":{"@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/#primaryimage"},"image":{"@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/#primaryimage"},"thumbnailUrl":"https:\/\/irbstage.vetim.ch\/images\/Slide1-4.jpg","datePublished":"2024-07-08T08:56:16+00:00","dateModified":"2024-07-08T09:03:56+00:00","breadcrumb":{"@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/"]}]},{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/#primaryimage","url":"https:\/\/irbstage.vetim.ch\/images\/Slide1-4.jpg","contentUrl":"https:\/\/irbstage.vetim.ch\/images\/Slide1-4.jpg","width":1280,"height":720},{"@type":"BreadcrumbList","@id":"https:\/\/irbstage.vetim.ch\/it\/news\/intestinal-secretory-iga-induction-protects-from-enteropathy-and-stunting-in-malnutrition\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/irbstage.vetim.ch\/it\/"},{"@type":"ListItem","position":2,"name":"News","item":"https:\/\/irbstage.vetim.ch\/.\/news\/"},{"@type":"ListItem","position":3,"name":"Intestinal secretory IgA induction protects from enteropathy and stunting in malnutrition"}]},{"@type":"WebSite","@id":"https:\/\/irbstage.vetim.ch\/it\/#website","url":"https:\/\/irbstage.vetim.ch\/it\/","name":"IRB USI","description":"Institute for Research in Biomedicine","publisher":{"@id":"https:\/\/irbstage.vetim.ch\/it\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/irbstage.vetim.ch\/it\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/irbstage.vetim.ch\/it\/#organization","name":"IRB USI","url":"https:\/\/irbstage.vetim.ch\/it\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/irbstage.vetim.ch\/it\/#\/schema\/logo\/image\/","url":"https:\/\/irbstage.vetim.ch\/images\/IRB-Usi.svg","contentUrl":"https:\/\/irbstage.vetim.ch\/images\/IRB-Usi.svg","width":98,"height":43,"caption":"IRB USI"},"image":{"@id":"https:\/\/irbstage.vetim.ch\/it\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/irbstage.vetim.ch\/it\/#\/schema\/person\/e3529a53127a78cf8ead39a83c87f29b","name":"Viviana Granelli"}]}},"_links":{"self":[{"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/posts\/35919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/users\/140"}],"replies":[{"embeddable":true,"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/comments?post=35919"}],"version-history":[{"count":5,"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/posts\/35919\/revisions"}],"predecessor-version":[{"id":35942,"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/posts\/35919\/revisions\/35942"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/media\/35916"}],"wp:attachment":[{"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/media?parent=35919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/categories?post=35919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irbstage.vetim.ch\/it\/wp-json\/wp\/v2\/tags?post=35919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}